Our Genes, Our Choices: How Genotype and Gene Interactions Affect
Behavior, Second Edition explains how the complexity of human
behavior, including concepts of free will, derives from a
relatively small number of genes, which direct neurodevelopmental
sequences. Are people free to make choices, or do genes determine
behavior? Paradoxically, the answer to both questions is "yes,"
because of neurogenetic individuality, a new theory with profound
implications. Here, author David Goldman uses judicial, political,
medical, and ethical examples to illustrate that this lifelong
process is guided by individual genotype, molecular and physiologic
principles, as well as by randomness and environmental exposures, a
combination of factors that we choose and do not choose. Written in
an authoritative yet accessible style, the book includes practical
descriptions of the function of DNA, discusses the scientific and
historical bases of genethics, and introduces the topics of
epigenetics and the predictive power of behavioral genetics. In the
decade since the first edition published, knowledge of genetic
influences on the neurogenetic underpinnings of behavior has been
transformed by genomic technologies. Genome-Wide Association
studies, for example, have revealed that hundreds of genes
influence vulnerability to psychiatric disease and innate
predisposition to risk-taking behaviors. This new edition has been
thoroughly revised to focus on free will and its neurogenetic
origins. In addition, the use of polygenic scores for behavioral
prediction are discussed in-depth, reflecting the GWAS (Genome-Wide
Association Study) revolution and combined use of genetic
predictors in polygenic scores. Sections on epigenetics are also
substantially expanded throughout, better defined, and tied to
neuroplasticity and gene-environment interaction. Figures and
illustrations have been added or improved throughout, and disease
nosology and terminology has been updated.Â
General
Imprint: |
Academic Press Inc
|
Country of origin: |
United States |
Release date: |
September 2023 |
First published: |
2024 |
Authors: |
David Goldman
|
Dimensions: |
229 x 152mm (L x W) |
Pages: |
304 |
Edition: |
2nd edition |
ISBN-13: |
978-0-443-22161-3 |
Categories: |
Books
|
LSN: |
0-443-22161-8 |
Barcode: |
9780443221613 |
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