Clinical Chemistry focuses on the laboratory diagnosis of the most
common diseases by organ system and relates diagnostic testing to
the pathophysiology of the diseases in development of the
differential diagnosis. Essential analytical methodology for
interpreting test results is fully integrated into discussions. The
second edition includes additional material such as newer cardiac
biomarkers soluble ST2, galexin-3, CD 146; hepatitis testing (A, B,
C, D, E); use of high-resolution serum protein electrophoresis;
procalcitonin; tumor markers such as neuron-specific enolase and
KRAS mutation; estimated glycated hemoglobin and glucose "time in
range" for monitoring glucose control; identification of specific
islet-cell antibodies in type 1 diabetes mellitus; discussion of
all types of diabetes mellitus; and more drugs for therapeutic
monitoring (lithium, methotrexate). Current reference intervals and
nomenclature have been used throughout, and additional summary
tables have been added where appropriate. New clinical cases are
included in every chapter.
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