Transcription, or the process by which DNA produces RNA, is a
central aspect of gene expression. Transcription factors regulate
transcription during development and in disease states. As such, it
is critical for researchers to gain a good understanding of the
relationship between the structure of various families of
transcription factors and their function, as well as roles in human
disease. Since publication of the Fourth Edition, there have been
major advances, notably in the areas of chromatin remodeling and
genome-scale analyses. This complete update includes all new
coverage of the latest developments, from enabling genomic
technologies to studies on the importance of post-translational
modifications beyond phosphorylation events.
Brand new coverage in this edition includes:
* Potential of transcription factors as therapeutic targets in
human disease
* Importance of histone modifications
* Use of genome-based sequence analysis and high-throughput methods
* Applications of the chromatin immunoprecipitation (ChIP) assay
* Transcriptional elongation
* Regulation by post-translational modifications
* Regulatory networks and bioinformatics
General
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