Ghrelin is a 28-amino acid peptide mainly secreted by the stomach.
To better understand the role of ghrelin signalling, this book
first explores the regulation of age-associated adipose tissue
inflammation. Following this, the authors discuss the influence of
different variables on the response of short-term appetite
regulation induced by exercise. External factors such as
temperature and environment exert effects on hormonal responses,
including hunger sensation and energy intake. The effects of gender
differences and aging on psychological stress-dependent eating
disorders are assessed, and the involvement of endogenous ghrelin,
the serotonin 2c receptor and the estrogen alpha receptor is
discussed. The penultimate chapter reviews the relationship between
sleep and eating behavior, focusing in the influences of circadian
changes on appetite related responses such as plasma concentration
of ghrelin. The concluding study highlights the ghrelin system as a
promising candidate for cardiovascular drug discovery, a new
therapeutic approach for the treatment of endothelial impairment,
and a possible contribution to the prevention of atherosclerosis.
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