The purpose of the present investigation was to design and evaluate
sustained release tablets of a sparingly water soluble drug
Ambroxol Hydrochloride, two hydrophilic polymers METHOCEL K15MCR
and METHOCEL K100MCR and hydrophobic Eudragit RL100 were used in
tablets prepared by direct compression. The granules were evaluated
for angle of repose, loose bulk density, tapped bulk density,
compressibility index, total porosity and drug content. The tablets
were subjected to various tests for physical parameters such as
thickness, hardness and friability, and in vitro release studies.
The in vitro dissolution study was carried out for 12 hours using
United States Pharmacopoeia (USP) paddle-type dissolution apparatus
(Apparatus 2) in phosphate buffer (pH 6.8). The results of
dissolution studies indicated that formulations containing Methocel
K100 MCR showed better dissolution properties compared to
formulaitons containing Methocel K15 MCR.It was found that
Hydrophilic polymers showed better released profile than the
hydrophobic polymers.
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