The purpose of the present work was to design & evaluate
sustained release tablets of Nifedipine, employing hydrophilic
polymer to improve dissolution rates of the drug. METHOCEL K15MCR
& METHOCEL K100LVCR were used in tablets prepared by direct
compression. The formulated tablets were physicochemically
characterized & results were found in acceptable limits. Poor
aqueous solubility of Nifedipine leads to variable dissolution
rates. The main effect & interaction terms were quantitatively
evaluated using mathematical models. Dissolution data were fitted
to zero order, first order, Higuchi's, Korsmeyer-Peppas &
Hixson-Crowell release kinetics to evaluate kinetic data. The drug
release data fit well to the Higuchi expression, but a close
relationship was also noted with zero order kinetics. Korsmeyer's
plot indicated that the drug release mechanism from the matrix
tablet was to be found Fickian mechanism. Regulated drug release
study indicate that the matrix tablets of Nifedipine prepared using
above polymers can successfully be employed as twice-a-day oral
controlled release dosage form.
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