The aim of present research work is to develop single pulse
pulsatile release tablets that release Lornoxicam instantly after
the lag time of about 5 hour which can be used for treatment of
rheumatoid arthritis where symptoms are at their prime in the
morning hours. Such a pulsatile release tablet of Lornoxicam taken
at bed time and release the drug in early morning, thus enhance
patient compliance. From various approaches erodible compression
coating system is selected for the formulation of pulsatile release
tablets, in which outer coating containing mixture of hydrophilic
polymer (sodium alginate) and hydrophobic polymer (ethylcellulose).
The release profile of compression coated tablet exhibited lag time
followed by burst release, in which outer shell break into two
halves.
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