It is well established that the vascular endothelium consists of a
single layer of endothelial cells (ECs) that lines the entire
vascular system, which plays an important role in vascular
homeostasis, immune and inflammatory reactions. The endothelial
cells exert significant autocrine, paracrine and endocrine actions
and influence smooth muscle cells, platelets and peripheral
leucocytes. It represents an important barrier between the blood
and the underlying interstitium and cells and has a major role in
the regulation of vascular tone, producing several vasoactive
mediators. This book examines up-to-date research regarding the
role of endothelial functions in terms of atherosclerosis and its
clinical manifestations.
General
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