Novel properties of engineered nanoparticles that make them
attractive may also present unique exposure risks. The traditional
physiologically-based pharmacokinetic (PBPK) modeling assumption of
instantaneous equilibration likely does not apply to nanoparticles.
This simulation-based research begins with development of a model
that includes di usion, active transport, and carrier mediated
transport. Eigenvalue analysis was used to examine model behavior
to focus future research. Results show that cellular transport
processes greatly a ect biokinetics of nanoparticles. The new
paradigm established by this research leverages traditional in
vitro, in vivo, and PBPK modeling, but includes area under the
curve to bridge animal testing results to humans. This allows
assessment of risk and assists in setting appropriate exposure
limits. The model provides critical understanding of nanoparticle
biokinetics and allows estimation of total exposure. This e ort
highlights future research needs and demonstrates how modeling can
be used as a tool to advance nanoparticle risk assessment.
General
Imprint: |
Biblioscholar
|
Country of origin: |
United States |
Release date: |
October 2012 |
First published: |
October 2012 |
Authors: |
Dirk P Yamamoto
|
Dimensions: |
246 x 189 x 11mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
208 |
ISBN-13: |
978-1-249-83101-3 |
Categories: |
Books >
Social sciences >
Education >
General
|
LSN: |
1-249-83101-6 |
Barcode: |
9781249831013 |
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