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Essential Concepts in Toxicogenomics (Paperback, Softcover reprint of hardcover 1st ed. 2008)
Loot Price: R2,885
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Essential Concepts in Toxicogenomics (Paperback, Softcover reprint of hardcover 1st ed. 2008)
Series: Methods in Molecular Biology, 460
Expected to ship within 10 - 15 working days
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The field of toxicogenomics is moving rapidly, so it is impossible
at the timeofthiswritingtocompileaclassicmethodstextbook.Instead,
wechose to identify experts in all aspects of this field and
challenged them to write reviews, opinion pieces, and case studies.
This book covers the main areas important to the study and use of
toxicogenomics. Chapter 1 speaks to the
convergenceofclassicapproachesalongsidetoxicogenomics.Chapter2deals
withtheusefulnessoftoxicogenomicstoidentifythemechanismoftoxicity.
Chapter3callsattentiontotheissuesthataffectthequalityoftoxicogenomics
experiments, as well as the implications of using microarrays as
diagnostic devices. The need for appropriate statistical approaches
to genomic data is discussed in Chapter 4, and Chapters 5 and 6
describe the use of genomic
datatobuildtoxicogenomicmodelsandprovideinsightsfromtheapproaches
oftwocompanies.Theimportanttopicofstoringthedatageneratedinsuch
experiments and the correct annotation that must accompany such
data is considered in Chapter 7. The discussion in Chapter 8 speaks
to the use of
toxicogenomicstoidentifyspeciessimilaritiesanddifferences.Chapters9and
10dealwiththeuseofgenomicstoidentifybiomarkerswithinthepreclinical
andclinicalarenas.Biomarkerswillonlybeusefulifthecommunityatlarge
acceptsthemasmeaningful.Consortiaareimportanttodrivethisfunction,
and Chapter11discussescurrenteffortsinthisarea.Lastbutnotleast,
Chapter12
presentsaperspectiveontheregulatoryimplicationsoftoxicogenomicdataand
someofthehurdlesthatcanbeseeninitsimplicationinGLPstudies.Although
thisbooktendstofocusonpharmaceuticals, theissuesfacingtoxicologyare
sharedbythechemicalmanufacturers, thetobaccoindustry,
andtheirregulators. We want to thank our contributors for their
generous time and energy in providingtheirinsights.Sadly,
wemustnotetheunexpectedpassingofone ofourauthors,
Dr.JosephHackettoftheFDA.Joe'scontributionservesasa
testimonytohisaccomplishmentsinthisfield, andhisinsightwillbemissed
intheyearstoc
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