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Histological Typing of Thyroid Tumours (Paperback, 2nd ed. 1988. 2nd printing)
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Histological Typing of Thyroid Tumours (Paperback, 2nd ed. 1988. 2nd printing)
Series: WHO. World Health Organization. International Histological Classification of Tumours
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Knowledge of tumours of the thyroid gland has advanced consider-
ably in the 22 years that have elapsed since work was started on
the first edition of Histological Typing of Thyroid Tumours. In the
intro- duction to that volume it was recognized that the
definitions and clas- sifications put forward would need revision
in time, and the present text differs substantially from the first
edition. As far as is possible, however, the framework of the
classification proposed remains the same, as the original
classification was widely accepted and proved useful in many
studies. The link between the morphological type of thyroid tumour
and its epidemiology, natural history, function, prognosis and
response to therapy has been further strengthened since the first
edition. In par- ticular, the decision taken to separate papillary
and follicular carcino- mas and exclude a mixed papillary
follicular type has been well justi- fied. One of the major changes
has been the recognition that many tu- mours regarded 20 years ago
as small cell carcinoma were really ma- lignant lymphoma, and this
development has been incorporated into this edition, with increased
importance given to primary malignant lymphoma of the thyroid. Much
work has also been done on medul- lary carcinoma of the thyroid,
its link with mUltiple endocrine neo- plasia syndromes, and its
association in its inherited form with C-cell hyperplasia; this too
is recognized by an expanded section on this tu- mour.
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