Visually engaging and easy to use, Human Histology: A Text and Atlas for Physicians and Scientists covers the normal histology of every organ in the human body. This book presents full-page high-definition photomicrographs for organs and tissues, followed by a compact and simple-to-read description of the structures identified on the micrographs, offering a clear, visual understanding of this complex subject. With over 300 outstanding images, this reference is an invaluable resource for every clinical researcher and pathologist in need of easily accessible, relatively simple but detailed enough information on normal histology of different organs systems. Due to its compact, but detailed layout, the volume is an excellent tool for medical board review and can be recommended for medical students and histology course directors.

"Methods of Adipose Tissue Biology" is a must-have for anyone interested in obesity or the physiology of white or brown adipose tissues. It contains state-of-the-art methods from researchers who are world leaders in this field. Detailed lab protocols include methods to visualize adipocytes and adipose tissues in humans and experimental models, converting stem cells into white and brown adipocytes in vitro, evaluating aspects of adipocyte metabolism, inducibly knocking out genes in adipose tissues, and evaluating transcriptional control of adipogenesis on a global scale.
The study of adipose tissue goes hand in hand with our global effort to understand and reverse the epidemic of obesity and associated medical complicationsContributors include leading researchers who have made tremendous contributions to our ability to investigate white and brown adipose tissuesThe wide variety of experimental approaches detailed within this volume: including the evaluation of adipose tissue biology at the molecular, biochemical, cellular, tissue, and organismal levels

For more than 30 years, "Current Topics in Developmental Biology" has provided a forum for dissemination and discussion of new ideas and thought in developmental biology. Bringing together a series of articles on the structural, functional, and developmental characteristics of epithelials, this thematic volume represents a timely and valuable contribution to an exciting and multidisciplinary field of study. Because defects in epithelial function and growth control play a major role in human disease-cancerous tumors, spina bifida, cardiac malformations, for example-this volume will be of particular interest to researchers working in cancer drug design and development and those working in therapeutic areas to treat developmental abnormalities.

Coverage of current research findings and thought on cell-cell and cell-extracellular matrix interactions gives researchers a better understanding of the processes of remodeling and morphogenesis, which are critical to the development of drugs aimed at disrupting the early formation and proliferation of cancerous tumors.

Inclusion of chapters that discuss the most contemporary thought on cell polarity and tissue morphogenesis, providing researchers with a better understanding of the control of cellular organization and polarity (particularly important to researchers who are developing treatments for developmental abnormalities and those working in cancer drug development).

Use of a variety of animal models, allowingresearchers to compare and contrast the molecular mechanisms that underlie cell-cell and cell-extracelluar matrix interactions in a variety of research models."

"Histopathology: Methods and Protocols "provides a comprehensive guide to the current issues in histopathology. With chapters on organ-based approaches with specificprotocols for morphologic, molecular examination and pathological observations governing the therapeutic management of the diseases. Written in the highly successful "Methods in Molecular Biology "series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, "Histopathology: Methods and Protocols "seeks to be a useful reference for pathologists, pathology residents and fellows as well as to the clinicians and scientists."

Specialists from diverse disciplines discuss the important topics of Tissue Repair and Fibrosis. The Role of Myofibroblast. The Myofibroblast is implicated in many processes, such as tissue repair,fibrosis, and stromal reaction to tumors. This book seeks to provide an overview of the knowledge accumulated since this cell was first describes 25 years ago. Discussions focusses on three main topics: - Cellular and molecular biology of fibroblast and myofibroblasts - Wound healing: experimental models, and - Human fibrocontracted diseases.

Histochemistry deals with the activities of chemical components in cells, and immunohistochemistry addresses the function of cell types in tissue or organs, such as those leading to acceptance or rejection of grafts or organs.

This book is a methods volume focusing on antigen retrieval, particularly methods used in disease-related antigens. Because the book is a methods volume and a lab manual, it will have an audience of pathologists, biochemists, and lab technicians.

Medical image technologies play a significant role in visualization and interpretation methods in medical diagnosis and practice using decision making, pattern classification, diagnosis, and learning. Progressions in the field of medical imaging lead to interdisciplinary discovery in microscopic image processing and computer-assisted diagnosis systems, and aids physicians in the diagnosis and early detection of diseases. Histopathological Image Analysis in Medical Decision Making provides emerging research exploring the theoretical and practical applications of image technologies and feature extraction procedures within the medical field. Featuring coverage on a broad range of topics such as image classification, digital image analysis, and prediction methods, this book is ideally designed for medical professionals, system engineers, medical students, researchers, and medical practitioners seeking current research on problem-oriented processing techniques in imaging technologies.

The justification for yearbooks is greater than ever as we approach the third millennium, overwhelmed with information. This first edition of the Cytokine Yearbook summarizes the latest advances in the revolutionary field of cytokine research. The work is not a comprehensive reference work, but covers a selection of current themes. The intention is to keep paying attention to current topics in the Yearbooks to come. The editors invited a number of distinguished colleagues, who are international experts in their specific fields, resulting in a high scientific level of the contributions. This Yearbook is required reading for every scientist and physician working in the field of cytokines.

Histotechnology and histomorphometry are the major methodologies in bone and cartila- related research. Handbook of Histology Methods for Bone and Cartilage is an outgrowth of the editors' own quest for information on bone and cartilage histology and histomorphometry. It is designed to be an experimental guide for personnel who work in the areas of basic and clinical bone and cartilage, orthopedic, or dental research. It is the first inclusive and organized reference book on histological and histomorphometrical techniques on bone and cartilage specimens. The topic has not previously been covered adequately by any existing books in the field. Handbook of Histology Methods for Bone and Cartilage has six major parts and is designed to be concise as well as inclusive, and more practical than theoretical. The text is simple and straightforward. Large numbers of tables, line drawings, and micro- or macro-photographs, are used to help readers better understand the content. Full bibliographies at the end of each chapter guide readers to more detailed information. A book of this length cannot discuss every method for bone and cartilage histology that has been used over the years, but it is hoped that major methods and their applications have been included.

The author, R.V. Krstic, is well-known internationally for his excellent histological drawings. This atlas is an excellent supplement to conventional histology textbooks, for students, teachers and professionals alike.

Up to date, easy to use, and rich with vibrant illustrations, Lippincott (R) Illustrated Reviews: Cell and Molecular Biology, 3rd Edition, provides a highly visual presentation of essential cell and molecular biology with a focus on topics related to human health and disease. This engaging approach incorporates all of the most popular features of the bestselling Lippincott (R) Illustrated Reviews series, including abundant full-color illustrations, chapter summaries, and review questions that link basic science to real-life clinical situations. The updated, versatile 3rd Edition can be used for a standalone cell biology course in medical, health professions, or other graduate and upper-level undergraduate programs; as a review for course and board exams; or in conjunction with other Lippincott (R) Illustrated Reviews for a seamless integrated course. UPDATED! Revised content throughout-including updated unit overviews and chapter summaries-helps students master the latest cell and molecular biology knowledge. UPDATED! Clinical Application boxes reinforce key concepts and enrich students' understanding and clinical application capability. More than 250 full-color, annotated illustrations clarify complex processes and simplify study. Online animations and interactive review questions strengthen comprehension and retention.

To produce a comprehensive overview of macrophages and related cell types in a short review volume is an impossible task. When I selected the topics to be included, some equally important areas were omitted by necessity, and for this I apologize. My choices have been somewhat eclectic, touching subjects of personal interest (such as osteoclast biology and macrophage electrophysiology) or of current fashion (apopto sis, antigen processing, cell adhesion molecules). The book has also had to encompass areas of a more general flavor to provide balance for the general reader (such as reviews of macrophage development, heterogeneity, and function, and of the surface molecules expressed by macrophages). I thank all the authors for their prompt sub missions; all have been of high quality, and my editorial tasks, thankfully, have been minimal. Michael A. Horton London, United Kingdom ix Contents Chapter J An Overview of Receptors of MPS Cells lain Fraser and Siam on Gordon 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. The Mononuclear Phagocyte System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3. Diversity of Macrophage Plasma Membrane Receptors. . . . . . . . . . . . . . . . 6 3. 1 A Structural Approach to Classification . . . . . . . . . . . . . . . . . . . . . . . . . . 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 2 Multisubunit Receptors 3. 3 Soluble Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. 4 Lectins and Lectin-Like Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. Functions and Selected Examples. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 4. 1 Growth, Differentiation, and Modulation . . . . . . . . . . . . . . . . . . . . . . . . 14 4. 2 Cell-Cell and Cell-Matrix Interactions. . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 3 Endocytosis and Scavenger Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 4 Secretory Responses and Biosynthesis of Effector Molecules . . . . . . 17 5. Concluding Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 6. References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 . . . . . . . . . . . . . . . . . . . ."

Master histology with idealized and actual photomicrography! This thirteenth edition of Atlas of Histology with Functional Correlations (formerly diFiore's ) provides a rich understanding of the basic histology concepts that medical and allied health students need to know. Realistic, full-color illustrations as well as actual photomicrographs of histologic structures are complemented by concise discussions of their most important functional correlations. Illustrated histology images show the idealized view, while photomicrographs provide the actual view to help students hone their skills in identifying structures. New and improved layout helps students connect the morphology of a structure with its function. Updated and expanded Functional Correlations boxes integrated throughout chapters reflect new scientific information and interpretations. NEW photomicrographs and electron micrographs provide views of microanatomy as experienced in practice. Bulleted Chapter Summaries distill the most essential knowledge for rapid review. NEW Additional Histologic Images sections round out each chapter with supplemental photomicrographs and electron micrographs. NEW Chapter Review Questions allow students to assess their comprehension of each chapter with 375 questions and answers in the book and 250 more online in an Interactive Question Bank.

The studies by Santiago Ram6n y Cajal on astrocytes, and the extense work developed by Pio del Rio Hortega dealing with microglia and oligodendrocytes are with no doubt two important milestones of neurobiology, and specially cf glial research. Since these classical studies, the curiosity for understanding glial cells has continuously grown. During the last two decades, the development of new meth- ods of study, including cell culture techniques and the use of histochemical and immunocytochemical markers, has allowed a remarkable advance in this field. This increasing interest is reflected by the creation of local and international glial networks, the publication of the journal Glia, the celebration of periodic interna- tional meetings and the publication of extensive books focused on glial cells. In February 1997, with the establishment of the Spanish Glial Network, arose the early idea of publishing a compendium of selected work by Spanish glial research teams, which has fmally materialised in Understanding Glial Cel/s, a book whose objective is to present topics of current interest in glial cell biology.

Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog ical situations (see below)."

Handbook of HLA Typing Techniques is an authoritative collection of HLA phenotyping and genotyping techniques to be used at the bench level and as a reference. The information presented, much of it previously unpublished, was written by leading authorities in the field of transplantation. Each chapter provides detailed methodologies, notes on the interpretation of tests, reference material, and appendices.

Phenotyping topics covered include microlymphocytotoxicity assay, monoclonal antibodies, complement testing, serum screening for HLA antibodies, lymphocytotoxic crossmatching, and mixed and primed lymphocyte testing. Genotyping topics discussed include well-established RFLP analysis and polymerase chain reaction applications of PCR-SSO, PCR-RFLP, PCR-SSP, and PCR fingerprinting and related DNA heteroduplex technologies. Handbook of HLA Typing Techniques is an indispensable sourcebook for all researchers, practitioners, and students in the international tissue typing and human immunogenetics community.

Master the essentials of oral biology with patient-centered approach. New illustrations and discussions of emerging issues keep you updated with advances in the dental professions and patient care. Written by Daniel J. Chiego Jr., and Professor Sausan Al Kawas both are experienced educators and researchers in oral histology and embryology, this book provides the basic science you need to succeed in the classroom and in clinical practice.

As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners.
* Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a wide range of drug metabolism studies-
* Provides a comprehensive description of different forms of metabolites, with detailed discussion on the wide range of methodologies used to identify them
* Highlights problems associated with drug quantification and offers practical solutions

Combiningtwodifferentscienti?cdisciplines-morphologyandimmunochemistry- immunohistochemistryhasdevelopedasanimportantinstrumentinresearchand clinicalpathology. A basicunderstandingofunderlying principlesandpotential problemsisunavoidableifyouwanttobesuccessfulinyouruseofimmunohis- chemistry,aswellasingettingyourpaperspublishedandyourresearchgrants funded. Whilemanyexcellenttextsandmonographsexistwhichcovervariousaspects ofimmunohistochemistry,thelackofaconcisecomprehensiveguidetousing thesemethodswasamajormotivationforwritingthisbook. Ourintentionwasto createaneasy-to-readandfocusedresourcebasedonstate-of-the-artinformation forabroadaudiencerangingfromstudentsandtechnicalassistantstoexperienced researchers. Thishandbookhasaconciseformat,withprotocolsandinstructionsfor methodsimmediatelyfollowingtheshortintroductorytheoreticalmaterialineach chapter. BeingconsciousofthegrowingroleofInternetasaninformationsource, wehavefounditreasonableinmanycasestosubstitutecitingbooksandjournal publications with corresponding Internet websites. Where possible, commercial sourcesofreagents,kits,andequipmentarelistedthroughoutthetextinsteadof inaseparateindex. Thougheachchapterissmallandintroductory,thishandbook itself is self-suf?cient and provides a comprehensive look at the principles of immunohistochemistry. For readers wanting further depth of knowledge, each chapterisbackedupbyashortlistofcarefullyselectedoriginalarticles. Duringthelastdecade,pioneeringeffortsofhistochemistshaveledtoan- menseimprovementinthereagentsandprotocols. Theresearcherisurgedalwaysto determinethereasonforeverymethodandstepbeforedoingit. Thishandbookis intendedtohelpreaderstoavoidtroublesinthechoiceofanadequatemethod,which happenswhenusingstandardtextbooks. Forthishandbook,wecarefullyselected establishedmethodsandeasy-to-adoptprotocols,payingattentiontomoderndev- opmentsinimmunohistochemistry,suchasantigenretrieval,signalampli?cation, the use of epitope tags in immunohistochemistry, multiple immunolabeling or diagnosticimmunohistochemistry. Eachofthemethodsdescribedinthishandbook v vi Preface was provedby the authors; many of these methods are routinely used in daily practiceintheirinstitute. Allthepracticalmethodsadvocatedareclearlydescribed, withaccompanyingtables,andtheresultsobtainableareillustratedwithcolour micrographs. Acknowledgements We thank Vera Samoilova forthe perfect technical assistance and other colleaguesfromtheMunsterUniversityClinicforsharingprobesandreagents. IgorB. BuchwalowandWernerBocker Munster Contents 1 AntibodiesforImmunohistochemistry ...1 1. 1 StructureofAntibodies ...2 1. 2 PolyclonalAntibodies ...4 1. 3 MouseMonoclonalAntibodies ...4 1. 4 RabbitMonoclonalAntibodies ...5 1. 5 ProteinAandProteinGinImmunohistochemistry ...7 References ...8 2 AntibodyLabelingandtheChoiceoftheLabel ...9 2. 1 CovalentLabelingofAntibodies ...9 2. 2 Non-CovalentLabelingofPrimaryAntibodieswith LabeledFabFragments ...10 2. 3 EnzymeLabelsforLightMicroscopy ...13 2. 4 FluorophoreLabelsforFluorescenceMicroscopy ...15 2. 5 ColloidalGoldLabelsforElectronMicroscopy ...16 References ...17 3 ProbesProcessinginImmunohistochemistry ...19 3. 1 FixationinImmunohistochemistry ...19 3. 1. 1 FixationinAlcoholsandAcetone ...20 3. 1. 2 FixationinFormaldehyde ...20 3. 1. 3 EffectofFormaldehydeFixationon Antigen-nster Contents 1 AntibodiesforImmunohistochemistry ...1 1. 1 StructureofAntibodies ...2 1. 2 PolyclonalAntibodies ...4 1. 3 MouseMonoclonalAntibodies ...4 1. 4 RabbitMonoclonalAntibodies ...5 1. 5 ProteinAandProteinGinImmunohistochemistry ...7 References ...8 2 AntibodyLabelingandtheChoiceoftheLabel ...9 2. 1 CovalentLabelingofAntibodies ...9 2. 2 Non-CovalentLabelingofPrimaryAntibodieswith LabeledFabFragments ...10 2. 3 EnzymeLabelsforLightMicroscopy ...13 2. 4 FluorophoreLabelsforFluorescenceMicroscopy ...15 2. 5 ColloidalGoldLabelsforElectronMicroscopy ...16 References ...17 3 ProbesProcessinginImmunohistochemistry ...19 3. 1 FixationinImmunohistochemistry ...19 3. 1. 1 FixationinAlcoholsandAcetone ...20 3. 1. 2 FixationinFormaldehyde ...20 3. 1. 3 EffectofFormaldehydeFixationon Antigen- immunohistochemistryhasdevelopedasanimportantinstrumentinresearchand clinicalpathology. A basicunderstandingofunderlying principlesandpotential problemsisunavoidableifyouwanttobesuccessfulinyouruseofimmunohis- chemistry,aswellasingettingyourpaperspublishedandyourresearchgrants funded. Whilemanyexcellenttextsandmonographsexistwhichcovervariousaspects ofimmunohistochemistry,thelackofaconcisecomprehensiveguidetousing thesemethodswasamajormotivationforwritingthisbook. Ourintentionwasto createaneasy-to-readandfocusedresourcebasedonstate-of-the-artinformation forabroadaudiencerangingfromstudentsandtechnicalassistantstoexperienced researchers. Thishandbookhasaconciseformat,withprotocolsandinstructionsfor methodsimmediatelyfollowingtheshortintroductorytheoreticalmaterialineach chapter. BeingconsciousofthegrowingroleofInternetasaninformationsource, wehavefounditreasonableinmanycasestosubstitutecitingbooksandjournal publications with corresponding Internet websites. Where possible, commercial sourcesofreagents,kits,andequipmentarelistedthroughoutthetextinsteadof inaseparateindex. Thougheachchapterissmallandintroductory,thishandbook itself is self-suf?cient and provides a comprehensive look at the principles of immunohistochemistry. For readers wanting further depth of knowledge, each chapterisbackedupbyashortlistofcarefullyselectedoriginalarticles. Duringthelastdecade,pioneeringeffortsofhistochemistshaveledtoan- menseimprovementinthereagentsandprotocols. Theresearcherisurgedalwaysto determinethereasonforeverymethodandstepbeforedoingit. Thishandbookis intendedtohelpreaderstoavoidtroublesinthechoiceofanadequatemethod,which happenswhenusingstandardtextbooks. Forthishandbook,wecarefullyselected establishedmethodsandeasy-to-adoptprotocols,payingattentiontomoderndev- opmentsinimmunohistochemistry,suchasantigenretrieval,signalampli?cation, the use of epitope tags in immunohistochemistry, multiple immunolabeling or diagnosticimmunohistochemistry. Eachofthemethodsdescribedinthishandbook v vi Preface was provedby the authors; many of these methods are routinely used in daily practiceintheirinstitute. Allthepracticalmethodsadvocatedareclearlydescribed, withaccompanyingtables,andtheresultsobtainableareillustratedwithcolour micrographs. Acknowledgements We thank Vera Samoilova forthe perfect technical assistance and other colleaguesfromtheMunsterUniversityClinicforsharingprobesandreagents. IgorB. BuchwalowandWernerBocker Munster Contents 1 AntibodiesforImmunohistochemistry ...1 1. 1 StructureofAntibodies ...2 1. 2 PolyclonalAntibodies ...4 1. 3 MouseMonoclonalAntibodies ...4 1. 4 RabbitMonoclonalAntibodies ...5 1. 5 ProteinAandProteinGinImmunohistochemistry ...7 References ...8 2 AntibodyLabelingandtheChoiceoftheLabel ...9 2. 1 CovalentLabelingofAntibodies ...9 2. 2 Non-CovalentLabelingofPrimaryAntibodieswith LabeledFabFragments ...10 2. 3 EnzymeLabelsforLightMicroscopy ...13 2. 4 FluorophoreLabelsforFluorescenceMicroscopy ...15 2. 5 ColloidalGoldLabelsforElectronMicroscopy ...16 References ...17 3 ProbesProcessinginImmunohistochemistry ...19 3. 1 FixationinImmunohistochemistry ...19 3. 1. 1 FixationinAlcoholsandAcetone ...20 3. 1. 2 FixationinFormaldehyde ...20 3. 1. 3 EffectofFormaldehydeFixationon Antigen-AntibodyBinding ...21 3. 2 Paraf?nSectionsforImmunohistochemicalAnalysis ...22 3. 2. 1 EmbeddingandCutting ...22 3. 2. 2 MountingParaf?nSectionsontoSlides ...23 3. 3 CryosectionsforImmunohistochemicalAnalysis ...24 3. 4 BuffersforWashingandAntibodyDilution ...25 3. 5 MountingFollowingImmunohistochemicalStaining ...27 3. 6 StorageFollowingImmunohistochemicalStaining ...28 References ...28 vii viii Contents 4 WorkingwithAntibodies ...31 4. 1 DirectImmunostainingMethod ...31 4. 2 IndirectImmunostainingMethod ...33 4. 3 TheChoiceofAntibodies ...35 4. 3. 1 TheChoiceofPrimaryAntibodies ...35 4. 3. 2 TheChoiceofSecondaryAntibodies ...

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism.

This book, which takes as its focus the biology and pathology of glial cells, pays special attention to the issues concerning the cellular and molecular interactions occurring between glia and neurons. Research over the last 30 years has shown that, contrary to previously held conceptions of the role of glial cells as being of secondary importance to that of neurons, they are major constituents of the nervous system, playing a pivotal role during development and adulthood. Moreover, recent evidence suggests that glial cells are involved in a number of disease states, some of which are still incurable, such as Alzheimer's disease, multiple sclerosis and other central and peripheral neuropathies. It is also well known that Schwann cells, the major glial cells of the peripheral nervous system, are unique in their ability to sustain and promote regeneration not only of peripheral but also of central neurons after traumatic injury. Thus the relatively new idea of repairing CNS damage through the transplantation of glial cells is an approach with great clinical potential. Bringing together contributions from expert researchers in the field, this is an informative and forward thinking approach to a continuously expanding field.

Lippincott (R) Connect Featured Title Purchase of the new print edition of this Lippincott (R) Connect title includes access to the digital version of the book, plus related materials such as videos and multiple-choice Q&A and self-assessments. The go-to tool for mastering histology, Gartner & Hiatt's Atlas and Text of Histology, 8th Edition, equips medical, dental, allied health, and biology students with a concise review of all of the major tissue classes and body systems in an engaging approach optimized for superior classroom and clinical success. A consistent presentation combines relevant text and detailed photomicrographs to facilitate understanding and provide valuable review for in-class and licensing examinations. Helpful explanatory text in each chapter details Histophysiology, Clinical Considerations, Summaries of Histologic Organization, and more, accompanied by more than 700 vivid, full-color, high-quality images. NEW! Streamlined organization aligns relevant text, figures, and Clinical Considerations in one place to help students study most effectively. NEW! Clinical vignette-style review questions provide valuable self-assessment and board exam preparation. More than 700 images - including colorful photomicrographs and illustration as well as clear electron micrographs - clarify relevant structures and anatomic relationships. Tissues That Resemble Each Other appendix hones students' ability to distinguish commonly confused tissues. Clinical Considerations demonstrate the link between histology and pathophysiology. Chapter Outlines and Summaries of Histologic Organization keep students focused on key concepts. Histologic Techniques chapter elucidates various stains and techniques. Abundant tables consolidate related topics for fast, efficient review. Lippincott (R) Connect features: Full access to the digital version of the book with the ability to highlight and take notes on key passages for a more personal, efficient study experience. Carefully curated resources, such as interactive diagrams, audio and video tutorials, and self-assessment, all designed to facilitate further comprehension. Lippincott (R) Connect also allows users to create Study Collections to further personalize the study experience. With Study Collections you can: Pool content from books across your entire library into self-created Study Collections based on discipline, procedure, organ, concept or other topics. Display related text passages, video clips and self-assessment questions from each book (if available) for efficient absorption of material. Annotate and highlight key content for easy access later. Navigate seamlessly between book chapters, sections, self-assessments, notes and highlights in a single view/page.

Histological techniques form the basis of many areas of research, yet they can often be poorly understood. Aimed at postgraduate students and those at an early stage of their career, this title provides a detailed and comprehensive introduction to histological techniques. With detailed images and slides, this book provides a unique overview of the area while providing the reader with a guide to how to use and incorporate histological techniques within their own research. Written by experts working within the field, this book is an essential handbook for anyone wanting to learn more about histological methods and how to apply them successfully.

Ace your courses and the USMLE with the go-to review guide-complete with critical concepts and fully updated practice questions Histology and Cell Biology is designed and formatted in a way that helps you make the most of your time, whether you're studying this topic for the first time or reviewing for the USMLE. With this focused review you'll be able to pinpoint your weak areas, then improve your comprehension with learning aids designed to help you understand and retain even the most difficult material. This popular LANGE guide provides everything you need to know about the four basic tissues types, and organs and organ systems. Each chapter is devoted to a specific topic and includes learning aids, such as objectives highlighting significant facts and concepts; study questions directing students to facts commonly covered on exams; synopsis presented in outline form that reviews all the basic histology and related cell biology covered on exams; and multiple-choice practice questions written in USMLE format. This authoritative resource concludes with a diagnostic final exam, updated with longer, case-related stems that mimic the USMLE Step 1 exam. NEW: Thoroughly revised Q&A NEW: Completely updated text and practice questions to reflect current knowledge NEW: Information added to each chapter regarding relevant pathology/clinical issues Good Text for first year students, help understand and piece together professors' lectures Great Practice Q&A