The progress in HLA research achieved in the last decade has been extremely beneficial for understanding of the human genome structure, evolution of human beings and the association between HLA and complex related factors like immune responsiveness and patomechanism of some diseases. It was also found that some HLA specificities may bear a witness not only to a susceptibility to some diseases but also may reflect the ability of the host to mount immune responsiveness. All these achievements enabled successful clinical application of haematopoietic stem cells transplantation. Nowadays, it is apparent that the perfect matching at allele level of HLA specificities constitute the most important factor affecting surviving of patients transplanted from unrelated donors. This is also shown in this volume. To secure reliability of HLA typing , DNA techniques should be implemented and laboratories should comply with requirements expressed by European Federation for Immunogenetics (EFI) and American Society for Histocompatibility and Immunogenetics (ASHI). HLA typing is a complex procedure which should involve internal and external quality controls. Haematopoietic stem cell transplantation may be the best example of introducing modern technologies and very active translation of basic research in the fields of genetics and cell biology into the clinic. Even more impressive is international collaboration in searching for the best possible donor wherever in the world it might be. More than 8 million donors are registered world-wide. There is an ongoing interest in improving the international co-operation in order to secure the best donors for recipients. These chapters are of special interest as the co-operation for donors selection for HSCT is an activity across the oceans.

Connective tissue is a multicomponent, polyfunctional complex of cells and extracellular matrix that serves as a framework for all organs, combining to form a unified organism. It is a structure responsible for numerous vital functions such as tissue-organ integration, morphogenesis, homeostasis maintenance, biomechanical support, and more. The regeneration potential of connective tissue affects healing of damaged tissue and organs, while trauma, stress, and other factors that cause damage to connective tissue can lead to numerous disorders. Connective Tissue: Histophysiology, Biochemistry, Molecular Biology brings together crucial knowledge of mammalian connective tissue (including human) and its components, both cellular and noncellular, in one authoritative reference. The breadth and depth of information has fundamental scientific significance as well as applied relevance in clinical medicine. The first half of the book covers the structure, classification, biochemical aspects, histogenesis, and cellular elements of connective tissue. It presents data from the macro- to nanolevel organization of the extracellular matrix-its structural and functional aspects-and addresses metabolic functions and the biochemistry and molecular biology of connective tissue ageing. The second half of the book reviews current data on the biochemistry and molecular biology of skeletal connective tissue, including bone and cartilage metabolism and regulation. It presents an in-depth analysis of data on the molecular mechanisms of connective tissue ontogenesis, from embryonic development through ageing. It also reports novel findings on bone marrow stroma and describes electron microscopy results of the nanostructure of bone mineral, mineralized cartilage, and teeth compared with coral and seashells. Comprising both classic and modern data on the histopathology, biochemistry, and molecular biology of connective tissue, this book provides a unique resource for clinicians and researchers alike.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Get the BIG PICTURE of Histology - and zero-in on what you really need to know to ace the course and board exams! A Doody's Core Title for 2020! 400 FULL-COLOR ILLUSTRATIONS Medical Histology: The Big Picture is a different kind of study tool. With an emphasis on what you "need to know" versus "what's nice to know", and featuring more than 400 full-color illustrations and micrographs, it offers a focused, streamlined overview of human histology. You'll find a succinct, user-friendly presentation designed to make even the most complex concepts understandable in a short amount of time. With just right balance of information to give you the edge at exam time, this unique combination text and atlas features: An efficient, study-enhancing design consisting of text on the left-hand page and related illustrations on the right-hand page - allowing you to grasp individual principles, one concept at a time The inclusion of detail, often clinical in nature, that clarifies the link between the structural and functional applications of histology Review questions and answers at the end of each chapter A complete final exam at the end of the book Icons that indicate high-yield, clinically relevant concepts Key Structures highlighted when they first appear to indicate their importance More than 400 full-color illustrations and micrographs depicting essential histology Concise, easy-to-remember bulleted text