As new techniques of transferring from liquid to gas phase and
measuring masses of drug molecules and metabolites become more
prevalent, so do the technical challenges of putting these
techniques into proper use, as well as the task of consolidating
emerging applications. Identification and Quantification of Drugs,
Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the
gap in the lack of presently available literature by providing a
critical review in the current use of liquid chromatography-mass
spectrometry (LC-MS) in drug discovery and development. With
chapters written by experts with a wide range of practical
experience from the pharmaceutical industry, emphasis is placed on
techniques and applications. The book also includes chapters on how
to utilize LC-MS instrumentation for current drug metabolism
problems. This book is intended for those beginning to use LC-MS
for drug metabolism studies as well as for those considered
advanced practitioners.
* Introduces readers to the practical applications of modern liquid
chromatography-mass spectrometry (LC-MS) in a wide range of drug
metabolism studies-
* Provides a comprehensive description of different forms of
metabolites, with detailed discussion on the wide range of
methodologies used to identify them
* Highlights problems associated with drug quantification and
offers practical solutions
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