This book is a fascinating overview of one of the first
pharmacogenetic traits to be identified as responsible for genetic
variation in response to drugs - the understanding of the arylamine
N-acetyltransferases (NATs) is linked to many important therapeutic
areas, particularly tuberculosis and also cancer. NATs have been
important in the metabolism of established anti-tubercular drugs
and also in carcinogenesis and susceptibility to bladder cancer.
The reach of these enzymes spans pharmacology and therapeutics as
well as toxicology and pharmacogenetics. The NAT genes are encoded
in a highly polymorphic region of the human genome which has been
explored for fine mapping in molecular anthropological studies.The
book takes a wide ranging approach covering all aspects of the
arylamine N-acetyltransferases from genetics to the chemistry and
structural biology of the enzymes in the organisms in which they
are found, from humans to bacteria and fungi where they appear to
have distinct roles. The coverage is by experts in the field from
across the globe.
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