Prostaglandin is a product of cyclooxygenase-2. Compelling
epidemiological and experimental studies over the last few decades
have suggested that elevated cyclooxygenase-2 activity has been
associated with enhanced development and spread of colorectal
cancer, although the exact mechanisms of action are largely unknown
or poorly understood. Modulation of adhesion molecules allows
colorectal cancer cells to break away from their primary site and
invade into the extracellular matrix: the initial process of
metastasis. Other molecules such as Metalloproteinases, Cluster
differentiation 44 and selectins are also thought to be involved.
This short book revisits these various processes of cancer
metastasis and reviews possible mechanisms of action with
cyclooxygenase on a molecular level. Furthermore, common intrinsic
and extrinsic modulators of cyclooxygenase are also discussed. This
important biological concept has potential pharmacological
implications with regards to chemo-prevention of cancer metastasis
- remains to be the leading cause of colorectal cancer deaths.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
United States |
Release date: |
September 2012 |
First published: |
September 2012 |
Authors: |
Edmund Leung
• Nigel Williams
|
Dimensions: |
229 x 152 x 6mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
100 |
ISBN-13: |
978-3-659-19311-8 |
Categories: |
Books >
Medicine >
General issues >
General
|
LSN: |
3-659-19311-9 |
Barcode: |
9783659193118 |
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