Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors (Hardcover)

An important new collection of clinical and preclinical reports on genetic therapy, this book describes illustrative examples of diseases in which gene-based interventions are presently plausible, and presents case studies of current research using both synthetic oligonucleotides and biological vectors. Combining the insights of over 50 contributors, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors -furnishes a historical overview of genetic therapy -highlights official Food and Drug Administration positions on the preparation of oligonucleotides and vectors -offers practical models of agent preparation, animal testing, pharmacokinetics, toxicology, and clinical trials -discusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indications -illustrates for new practitioners how each stage of genetic therapy is developed -details genetic treatment of leukemia; lymphoma; cancer of the brain, breast, colon, kidney, and lung; melanoma; HIV; and coronary restenosis -includes examples of antisense, ribozyme, tumor suppressor, immunostimulation, and gene replacement therapy -and addresses questions of preparation, delivery, toxicity, mechanism, and specificity.

General

Imprint:	Crc Press
Country of origin:	United States
Release date:	April 1998
First published:	1998
Editors:	Eric Wickstrom
Dimensions:	234 x 156 x 32mm (L x W x T)
Format:	Hardcover
Pages:	448
ISBN-13:	978-0-8247-0085-0
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > General Promotions
LSN:	0-8247-0085-6
Barcode:	9780824700850

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