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Vascular Medicine - From Endothelium to Myocardium (Paperback, Softcover reprint of the original 1st ed. 1997)
Loot Price: R1,546
Discovery Miles 15 460
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Vascular Medicine - From Endothelium to Myocardium (Paperback, Softcover reprint of the original 1st ed. 1997)
Series: Developments in Cardiovascular Medicine, 197
Expected to ship within 10 - 15 working days
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Based on a number of collaborative efforts between basic
researchers and clinicians from different institutions in Leiden,
this book covers the initial and promising results of these
efforts. The role of the endothelium, especially of the coronary
intravascular species is a relatively new and fascinating
development in the diagnosis and treatment of cardiac disease.
Three major aspects of endothelial function receive attention in
this volume: its regulatory role in myocardial function, evidence
for which is gradually forthcoming, with possible great
implications for disease states such as volume overload and failure
its role in the calcium metabolism of vascular smooth muscle cells
and the effects of calcium antagonists and the endothelial
dysfunction generated by coronary angioplasty and its possible
restoration by cholesterol reduction. The topic of imaging
atherosclerotic lesions in the coronary arteries is discussed with
the emphasis on advanced methods: single photon emission computed
tomography (SPECT), positron emission tomography (PET), and
magnetic resonance imaging techniques. A wholly new development is
the characterization of the atherosclerotic lesion by Raman
spectroscopy using a laser beam to illuminate the vascular wall.
Various aspects of inflammation related to the pathogenesis of
acute coronary syndromes, in particular unstable angina, are
illuminated, as well as the role of blood-borne substances as risk
factors for atherosclerosis. Transgenic mice carrying the gene for
human APOE*3 Leiden are being used successfully to study the
environmental and genetic factors that influence the remnant
lipoprotein metabolism. Possibilities for gene therapy to treat
atherosclerosis in the clinic are being investigated in animal
models. Finally, as the book is based on 50 years of Cardiology in
Leiden, the history of its development up to the present day is the
topic of a separate chapter. This book is intended for
cardiologists, internal medicine specialists, nuclear medicine
specialists, thoracic surgeons, cardiovascular radiologists and
basic scientists in the field of the cardiovascular system.
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