Calcium antagonists are currently the most extensively investigated
drugs for the treatment of heart disease. They are used worldwide
with great success and a comparatively low incidence of adverse
reactions. The most prevalent and threatening diseases in modem
industrialized societies - the various forms and complications of
coronary arteriosclerosis and arterial hypertension - are amenable
to treatment with calcium antagonists. The pharmacological spectrum
of calcium antagonists is highly specific and was supplemen ted a
few years ago by gallopamil, a verapamil analogue. The experimental
work reported at this symposium was concerned with effects of
gallopamil on the electrophysiology of the heart, particularly in
acute myocardial ischemia. New therapeutic features of myocardial
hypertrophy and hypertrophic cardiomyopathy are discussed. In
medical practice, gallopa mil has proved particularly useful for
the treatment of angina pectoris. Studies comparing gallopamil with
other calcium antagonists are described to profile the properties
of the drugs in terms of their specific therapeutic value. There is
still a need for more differential therapeutic trials. This first
international symposium on gallopamil was attended by experts from
institutions devoted to theoretical and clinical research and
general practice."
General
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