In the past two decades a number of studies have shown that
abnormalities in the function and structure of coronary
microcirculation can be detected in several cardiovascular
diseases. On the basis of the clinical setting in which it occurs,
coronary microvascular dysfunction (CMD) can be classified into
four types: CMD in the absence of any other cardiac disease; CMD in
myocardial diseases; CMD in obstructive epicardial coronary artery
disease; and iatrogenic CMD. In some instances CMD represents an
epiphenomenon, whereas in others it represents an important marker
of risk or may contribute to the pathogenesis of myocardial
ischemia, thus becoming a possible therapeutic target. This book
provides an update on coronary physiology and a systematic
assessment of microvascular abnormalities in cardiovascular
diseases, in the hope that it will assist clinicians in prevention,
detection and management of CMD in their everyday activity.
General
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