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Abnormal Hemoglobins in Human Populations (Hardcover)
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Abnormal Hemoglobins in Human Populations (Hardcover)
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Research on abnormal human hemoglobins (protein in blood that
carries oxygen), has taught us about the inheritance, biochemistry,
and distribution of these traits. This knowledge, coupled with
mathematical research using computer models of population genetics,
has enabled researchers to marry biological fact and genetic
theory. This volume places medical understanding in an evolutionary
framework. Using published data on the frequencies of abnormal
hemoglobins in the world's populations, Livingston analyzes and
interprets these frequencies in the light of world distribution of
different forms of diseases such as malaria. He further develops
the genetic theory of the evolutionary homeostasis. Livingston
discusses the relation of abnormal hemoglobins to endemic malaria
and, shows how natural selection pressures explain the known
distribution of these traits. Where non-coinciding distributions
arise, the book presents other genetic, anthropological,
evolutionary, and epidemiological evidence to explain these
discrepancies. This classic work remains a useful sourcebook for
professors and graduate students of anthropology, genetics,
epidemiology, and hematology.
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