Increased Cu levels in blood, saliva and brain are found in
Mn-exposed animals and humans; the underlying mechanism is unknown.
Dyshomeostasis of Cu in the central nervous system is known to
contribute to the pathogeneses of several neurodegenerative
diseases. Regulation of cellular Cu homeostasis involves
Cu-transporting ATPases (Cu-ATPases), i.e., ATP7A and ATP7b. Both
transporters play an important role in removing excess Cu ions from
the cytosol. However, the questions as to whether and how
Cu-ATPases in the brain barrier systems transport Cu, i.e., toward
brain parenchyma, cerebrospinal fluid, or blood, and whether and
how Mn exposure affects the transport function of both Cu-ATPases,
remained unanswered. This study was designed to characterize the
role of Cu-ATPases in regulating Cu transport at the blood-brain
and blood-cerebrospinal fluid barriers and to investigate how
exposure to Mn may alter the function of ATP7A and ATP7B, thereby
contributing to the etiology of Mn-induced Parkinsonian disorder.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
United States |
Release date: |
April 2014 |
First published: |
April 2014 |
Authors: |
Fu Xue
• Zhang Yanshu
• Zheng Wei
|
Dimensions: |
229 x 152 x 14mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
252 |
ISBN-13: |
978-3-659-52928-3 |
Categories: |
Books >
Medicine >
General issues >
General
|
LSN: |
3-659-52928-1 |
Barcode: |
9783659529283 |
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