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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Signaling Mechanisms in Protozoa and Invertebrates (Paperback, Softcover reprint of the original 1st ed. 1996)
Loot Price: R2,855
Discovery Miles 28 550
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Signaling Mechanisms in Protozoa and Invertebrates (Paperback, Softcover reprint of the original 1st ed. 1996)
Series: Progress in Molecular and Subcellular Biology, 17
Expected to ship within 10 - 15 working days
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Comparative endocrinology helps to find the roots of homeostatic
regulation in organisms. In this context, many years ago a series
of experiments were done, which demonstrated the hormonal regula
tion also on the invertebrate level. The mechanisms are partly
similar, partly different, from those found in vertebrates. The new
receptor era of mammalian endocrinology stimulated research on
invertebrate hormone receptors, and sophisticated methods are
applied also to determine hormones. The experiments demonstrated
the existence and even similar function of these structures and
signaling molecules. However, data on hormones and receptors at the
lowest level of metazoan life and the highest level of protozoan
life were not at our disposal. About two decades ago, first
observations on the presence of hormone receptors reacting to
vertebrate hormones in protozoa were made. Since the early 1980s we
know that hormone-like molecules similar to those of higher
vertebrates are present also in unicellular organisms. The presence
of some second messengers in Tetrahymena was recognized. Since
then, the research has been extended and many structures -
previously believed to be solely vertebrate characteristics, such
as opiate receptors, similar to mammalian ones - were found in
unicellular organisms. These observations justified the assumption
of a complete endocrine system at protozoan level, where -
considering the unicellularit- this seemed to be not required.
However, it became clear that the roots of endocrine communication
date back at least 2 billion years."
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