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Epidemiology and Biology of Multiple Myeloma (Paperback, Softcover reprint of the original 1st ed. 1991)
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Epidemiology and Biology of Multiple Myeloma (Paperback, Softcover reprint of the original 1st ed. 1991)
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On March 27, 1990, the National Cancer Institute sponsored a
workshop on the epidemiology of multiple myeloma, held at the
National Institutes of Health. This book comprises articles
prepared by participants in this work shop. Discussed in these
papers are: the descriptive and analytic epidemi ology, differences
in risk factors between blacks and whites, monoclonal gammopathies
and their progression, and hypotheses regarding the etiology and
pathogenesis of multiple myeloma. Several epidemiologic research
areas received particular attention during this workshop, and are
reviewed in detail in this volume. There have been striking
increases in the incidence of multiple myeloma over the past thirty
years, especially among older individuals and blacks, which may not
be entirely explained by changes in diagnostic capabilities.
Occupational and environmental exposures have been associated with
an increased risk of multiple myeloma, including farming exposures,
occupational exposure to petroleum and rubber processing, exposure
to ionizing radiation, and asso ciations with persistent virus
infections. The most striking epidemiological finding is reflected
in the differences in incidence rates of multiple myeloma which are
twice as high in blacks as compared with whites. Further, since
1950 the mortality rates for multiple myeloma have quadrupled in
blacks while doubling for whites. Among hematopoietic malignancies,
multiple myeloma is the only one with increased incidence and
mortality rates among blacks. 1\vo major possibilities for
explaining ethnic/racial differences in suscepti bility to multiple
myeloma are genetic and environmental factors.
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