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Bioadhesive Drug Delivery System For a Cardiovascular Drug (Paperback)
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Bioadhesive Drug Delivery System For a Cardiovascular Drug (Paperback)
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Market for advanced drug delivery systems has undergone a period of
innovation and significant expansion over the past decade.In this
context worldwide market for transmucosal products is in excess of
five billion annually and is expected to continue to grow at a
rapid pace.Hence transmucosal drug delivery holds lot of promise in
the coming era. Amongst various transmucosal routes buccal region
of the oral cavity has got optimal attributes for transmucosal and
modified drug delivery and has lot of promise and commercial
viability.Present work encompasses development of extended release
formulation of an antihypertensive drug Nisoldipine using
bioadhesive polymers, to improve the bioavailability along with
minimal variation in the therapeutic response. Nisoldipine is a
calcium channel blocker of the dihydropyridine class. Nisoldipine
is an ideal candidate for this work as its bioavailability is 4-8%
and has high inter and intrasubject variability in response.Studies
include formulation development using Progressive Hydration
Technology, optimizing and validating the formulation approaches,
stability studies and in-vivo evaluation in rabbits.
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