Leading basic and clinical investigators from around the world
summarize the most recent research on the molecular and cellular
origins of lupus. Their cutting-edge articles review the mechanisms
underlying abnormal immunity and introduce the powerful new concept
that a disorder of multiple genes underlies the abnormal immune
response, leading directly to the development of lupus. This
pathophysiology is shown to involve a wide variety of cell types,
including T cells, B cells, natural killer cells,
macrophages/monocytes, and endothelial cells. Over time, the
resulting long-term inflammation causes irreversible cell
destruction and, ultimately, organ failure. Lupus: Molecular and
Cellular Pathogenesis is a masterful new synthesis of all the new
knowledge emerging today about lupus. Its new perspectives will
sharpen the focus of research and ultimately lead to better and
more effective treatment.
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