Optimization in Drug Discovery - In Vitro Methods (Paperback, Softcover reprint of the original 2nd ed. 2014)

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve "drug-like" characteristics in addition to efficacy properties and good safety profiles of drug candidates. Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Pharmacology and Toxicology
Release date:	August 2016
First published:	2014
Editors:	Gary W. Caldwell • Zhengyin Yan
Dimensions:	254 x 178 x 31mm (L x W x T)
Format:	Paperback
Pages:	597
Edition:	Softcover reprint of the original 2nd ed. 2014
ISBN-13:	978-1-4939-6070-5
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General
LSN:	1-4939-6070-9
Barcode:	9781493960705

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