Acute and chronic administration of Oxalis corniculata L. has
anti-epileptic activity against MES and INH induced convulsions by
reducing tonic hind limb extension phase and delaying onset of
convulsion. It also observed that plant extract possess
anti-psychotic activity against apomorphine induced stereotyped
behavior and haloperidol induced catalepsy by reducing the
stereotyped behavior as well as potentiated the cataleptic score.
Anti-epileptic activity of Oxalis corniculata L. may be attributed
to the involvement of either by blocking the Na+ channels or
enhancing the GABAergic system in the neuronal of the brain.
Furthermore, anti-psychotic activity of Oxalis corniculata may be
due to involvement of dopaminergic pathway. The identification of
active constituents with anti-epileptic and anti-psychotic activity
from this plant may provide new directions for identification of
active neuropharmacological agents, which could be given
concomitantly during epilepsy and psychosis. These results suggest
that the Oxalis corniculata L. have potential clinical application
in the management of epilepsy and psychiatric disorders.
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