The objective of this study was to optimize a periodontal drug
delivery system containing antibacterial drugs having synergistic
activity for the treatment of mixed periodontal infections.
Periodontal pockets provide natural reservoir bathed by gingival
crevicular fluid that is easily accessible for the insertion of a
delivery device. Controlled release delivery of antimicrobials
directly into periodontal pockets has received great interest and
appears to hold a sound promise in periodontal therapy. Both
topical drug delivery and controlled drug release have been termed
as local drug delivery. It does not substitute the local
instrumentation but acts as an adjunct to it. The periodic use of
local drug delivery in minimizing bleeding, stabilizing attachment
levels and thereby reducing probing depth, would allow better
control and management of periodontal disease. Various drugs have
been under investigation for more than 3 decades promising
encouraging results. The rationales of using antibacterial drugs
through local delivery into the periodontal pockets have been
discussed.
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