Human African trypanosomiasis or sleeping sickness is caused by
infection with the morphologically indistinguishable subspecies
Trypanosoma brucei rhodesiense (in East and Southern Africa) and
Trypanosoma brucei gambiense (in West and Central Africa). The
disease is presently almost under control and less than 4000 cases
are currently reported. In both, T. b. rhodesiense and T. b.
gambiense infection, after the injection of infective metacyclic
trypanosomes with tsetse fly vector saliva, the parasites establish
in the skin, differentiate to the bloodstream stage and spread via
the local draining lymph node into the vascular system. In this
book, Chapter One presents an overview of the current epidemiology,
clinical features, diagnosis and treatment options. Chapter Two
provides an in-depth review of diagnostic methods for African
trypanosomiasis. Chapter Three discusses the use of aminoadamantane
derivatives against Trypanosoma brucei.
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