Resolving the Cholesterol Controversy recounts the science and
scientific personalities behind the chain of discoveries upon which
the lipid hypothesis of atherosclerosis was built.The narrative
covers a period of just under 100 years, starting with Anitschkow's
experiments with cholesterol-fed rabbits in 1913, and recounts the
endeavours and achievements of the leading actors in this
protracted scientific drama. The cast is drawn from an
extraordinary variety of scientific disciplines: pathology,
biophysics, epidemiology, nutrition, cardiology, lipidology,
genetics, microbiology, pharmacology, and clinical trial design.
Most of the scientists believed that cholesterol played a causal
role in atherosclerosis and cardiovascular disease, but there were
some who dissented strongly from this conclusion.The breadth of
scientific disciplines involved in proving the lipid hypothesis is
matched by the geographical spread of the participants. Anitschkow
worked in Russia, Endo discovered the first statin in Japan, their
commercial development by Merck took place in the USA and evidence
of benefit from lowering cholesterol came from trials conducted in
Scandinavia and the UK. The subsequent meta-analysis of these
statin trials in 2005 proved the validity of the lipid hypothesis
beyond any doubt. The history of how this all came about and its
impact upon health policy and medical practice is recalled here in
Resolving the Cholesterol Controversy.
General
| Imprint: |
World Scientific Europe Ltd
|
| Country of origin: |
United Kingdom |
| Release date: |
July 2023 |
| First published: |
2023 |
| Authors: |
Gilbert R. Thompson
|
| Format: |
Hardcover
|
| Pages: |
248 |
| ISBN-13: |
978-1-80061-397-3 |
| Categories: |
Books
|
| LSN: |
1-80061-397-0 |
| Barcode: |
9781800613973 |
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