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Manual of Cardiovascular Proteomics (Hardcover, 1st ed. 2016)
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Manual of Cardiovascular Proteomics (Hardcover, 1st ed. 2016)
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This book fulfils the need to keep up with the high number of
innovations in proteomics, and at the same time to warn the readers
about the danger of manufacturers and scientists claims around new
technologies. Mass spectrometry stands as the core technology in
proteomics. The emerging field of targeted proteomics and its
potential applications in the cardiovascular arena are also
reviewed and discussed. A concluding section highilghts the promise
of proteomics in the light of these recent developments. As this
technique and its applications have undergone remarkable advances
in the past years, recent updates on proteomic applications are
covered. Another key concept revealed by proteomic technologies is
that the extent of protein post-translational modifications (PTMs)
as well as their impact on the phenotype has been underestimated by
pre-proteomics science. As such, part of the manual focuses on the
emerging role of PTMs in basic cardiovascular sciences and in the
clinics. In fact, there is an emerging consensus that the detailed
annotation of protein PTMs could lead to a more in-depth
representation of biological systems, translating into more
specific targets for therapy as well as biomarkers. Moreover, a
recent trend is so-called "targeted proteomics". The approach was
awarded the title of "Method of the Year" by Nature in 2013 (see
the editorial by Vivien Marx in 1st issue of Nature in Jan 2013).
According to a few proteomic scientists the emphasis should not be
placed on generating long lists of proteins but lists of proteins
with a true biological meaning.
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