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Enhancing the buccoadhesive potential of a cellulose derivative (Paperback)
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Enhancing the buccoadhesive potential of a cellulose derivative (Paperback)
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Bioadhesive formulations have a wide scope of application for both
systemic and local effects of the drug. The oral transmucosal drug
delivery bypasses liver and avoids pre-systemic elimination. The
strategies to overcome such obstacles include the employment of new
materials that, possibly, combine mucoadhesive and penetration
enhancer properties and the design of novel drug delivery systems
which, besides improving patient compliance, favor a more intimate
contact of the drug with the absorption mucosa. Cellulose
derivatives like HPMC is having good mucoadhesive property however
it's potential can be increased by inclusion of plant derived gum
like gum karaya. Diclofenac is a non-steroidal anti-inflammatory
drug (NSAID) with pain relieving properties. It is used to treat
many painful conditions, inflammation, swelling, and /or stiffness
caused by several conditions and acute postoperative pain. One form
of diclofenac, the potassium salt, is more effective at the same
dose than the other form of diclofenac, the sodium salt. In view of
first pass effect it has been selected as model drug for the study.
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