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Bioreactors - Animal Cell Culture Control for Bioprocess Engineering (Paperback)
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Bioreactors - Animal Cell Culture Control for Bioprocess Engineering (Paperback)
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Bioreactors: Animal Cell Culture Control for Bioprocess Engineering
presents the design, fabrication, and control of a new type of
bioreactor meant especially for animal cell line culture. The new
bioreactor, called the "see-saw bioreactor," is ideal for the
growth of cells with a sensitive membrane. The see-saw bioreactor
derives its name from its principle of operation in which liquid
columns in either limb of the reactor alternately go up and down.
The working volume of the reactor is small, to within 15 L.
However, it can easily be scaled up for large production in volume
of cell mass in the drug and pharmaceutical industries. The authors
describe the principle of operation of the see-saw bioreactor and
how to automatically control the bioprocess. They discuss different
control strategies as well as the thorough experimental research
they conducted on this prototype bioreactor in which they applied a
time delay control for yield maximization. To give you a complete
understanding of the design and development of the see-saw
bioreactor, the authors cover the mathematical model they use to
describe the kinetics of fermentation, the genetic algorithms used
for deriving the optimal time trajectories of the bioprocess
variables, and the corresponding control inputs for maximizing the
product yield. One chapter is devoted to the application of time
delay control. Following a description of the bioreactor's working
setup in the laboratory, the authors sum up their investigation and
define the future scope of work in terms of design, control, and
software sensors.
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