This book comprehensively reviews the association of homocysteine
metabolism with the etiology of various human disorders. The
well-defined chapters embedded the central and peripheral effects
of homocysteine metabolism intricately related with
cardiovascular, neurodegenerative, metabolic, and autoimmune
disorders. Further, it discusses the mechanisms of perturbance of
cellular proteostasis by elevated homocysteine levels and provides
a comprehensive account of pathophysiological consequences and
clinical implications of homocysteine-containing proteins. The book
also reviews association of genetic variants of homocysteine
metabolic genes with type 2 diabetes mellitus and obesity. It also
describes the molecular mechanism of hyperhomocysteinemia in the
negative/feedback regulation of neural stem cell proliferation and
alterations in DNA methylation. Taken together, it summarizes the
mechanisms of hyper homocysteinemia-induced endothelial dysfunction
and physiological functions of hydrogen sulfide as the protective
agent.
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