Metalloproteins comprise approximately 30% of all known
proteins, and are involved in a variety of biologically important
processes, including oxygen transport, biosynthesis, electron
transfer, biodegradation, drug metabolism, proteolysis, and
hydrolysis of amides and esters, environmental sulfur and nitrogen
cycles, and disease mechanisms. EPR spectroscopy has an important
role in not only the geometric structural characterization of the
redox cofactors in metalloproteins but also their electronic
structure, as this is crucial for their reactivity. The advent of
x-ray crystallographic snapshots of the active site redox cofactors
in metalloenzymes in conjunction with high-resolution EPR
spectroscopy has provided detailed structural insights into their
catalytic mechanisms.
This volume was conceived in 2005 at the Rocky Mountain
Conference on Analytical Chemistry (EPR Symposium) to highlight the
importance of high-resolution EPR spectroscopy to the structural
(geometric and electronic) characterization of redox active
cofactors in metalloproteins. We have been fortunate to have
enlisted internationally recognized experts in this joint venture
to provide the scientific community with an overview of
high-resolution EPR and its application to metals in biology. This
volume, High-Resolution EPR: Applications to Metalloenzymes and
Metals in Medicine, covers high-resolution EPR methods, iron
proteins, nickel and copper enzymes, and metals in medicine. An
eloquent synopsis of each chapter is provided by John Pilbrow in
the Introduction.A second volume, Metals in Biology: Applications
of High-Resolution EPR to Metalloenzymes, will appear later this
year covering the complement of other metalloproteins.
One of the pioneers in the development of pulsed EPR and its
application to metalloproteins was Arthur Schweiger, whose
contribution we include in this volume. Unfortunately, he passed
away suddenly during the preparation of this volume. The editors
and coauthors are extremely honored to dedicate this volume to the
memory of Arthur Schweiger in recognition of his technical advances
and insights into pulsed EPR and its application to
metalloproteins. Arthur was extremely humble and treated everyone
with equal respect. He was a gifted educator with an ability to
explain complex phenomena in terms of simple intuitive pictures,
had a delightful personality, and continues to be sadly missed by
the community.
It is an honor for the editors to facilitate the dissemination
of these excellent contributions to the scientific community.
Suggestions for future volumes are always appreciated."
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