Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted
glycoprotein that stimulates the proliferation and differentiation
of granulocyte precursor cells, and induces mobilization of
peripheral blood progenitor cells from the bone marrow. Development
of recombinant human G-CSF has had a profound impact on the
treatment of many diseases, including severe chronic neutropenia
and cancer, and has enabled peripheral stem cell transplantation to
supplant bone marrow transplantation in the autologous setting.
This Milestones in Drug Therapy volume describes the experience of
the last 20 years of treatment with recombinant human G-CSF,
including the basic science, the use of recombinant human G-CSF in
both the oncology and nononcology settings, and the safety and
economics of its use. Many of the authors were the original
investigators of recombinant human G-CSF and other authors are key
researchers who provide their outlook for the next 20 years for use
of and research with recombinant human G-CSF.
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