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Molecular Diagnostics for Dermatology - Practical Applications of Molecular Testing for the Diagnosis and Management of the Dermatology Patient (Hardcover, 2014 ed.)
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Molecular Diagnostics for Dermatology - Practical Applications of Molecular Testing for the Diagnosis and Management of the Dermatology Patient (Hardcover, 2014 ed.)
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This textbook presents the current (and near-future) state of
affairs of molecular testing as it pertains to the dermatology
patient. It focuses on practical applications of molecular
diagnostics over a cross-section of dermatologic disease, including
melanoma, lymphoma, soft tissue tumors, genodermatoses, and
infectious disease. It includes practical advice to those ordering
molecular tests as well as to those considering performing such
tests, providing a potential template for a comprehensive
dermatologic molecular diagnostics test menu. Pitfalls of
interpretation and algorithmic approaches to testing are included.
The textbook is directed towards all readers - clinicians,
pathologists, laboratorians, and other inquisitive minds -
independent of their level of molecular expertise, to provoke
thought or perhaps even change practice. The context for the book
is the rapid evolution of the field of molecular diagnostics, which
is becoming more pervasive in all disciplines of medicine,
including dermatology. This is indeed an exciting time in
dermatology. Molecular testing is now incorporated into all aspects
of patient management, including diagnostics (identifying and
classifying disease), prognostics (predicting disease course), and
theranostics (predicting response to therapy). For example,
molecular tests are now used to detect germline mutations that
result in genodermatoses, somatic genetic events that characterize
tumors such as melanoma and sarcomas, and genetic material of
otherwise undetectable infectious organisms. For melanoma and
lymphoma, testing can potentially predict tumor behavior and modify
patient staging. Regarding theranostics, molecular tests that
identify specific mutations in proto- oncogenes, such as BRAF and
others, are now used to predict which patients will respond to
designer targeted therapies. Molecular theranostics has
revolutionized the entire treatment paradigm for patients with
advanced melanoma, repla
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