Contraceptive research has entered the new age of vaccines.
Realistic prospects exist for the development of an entirely new
battery of vaccines for use in human and veterinary medicine. Among
them may be anti-fertility vaccines, based on physiological
mechanisms applicable to either the female or male. This volume is
a comprehensive review - a status report - of the subjects
including fundamental work on the search for useful epitopes and
ranging to applied vaccinology. One vaccine to prevent pregnancy,
for use by women, has already been studied extensively. G.P.
Talwar, the volume's editor and his colleagues in New Oelhi, India,
published in 1976 a landmark series of papers describing the
immunological properties of a preparation consisting of the
alum-precipitated beta-subunit of human chorionic gonadotropin
(hCG) chemically linked to tetanus toxoid. The principle of
enhancing antigenicity of a self-protein by linkage of the epitope
to a carrier protein was employed and tested clinically. These
trials, carried out under the auspices of the Indian Council for
Medical Research, were the first application of the carrier protein
concept for a vaccine for human use. The encouraging results
stimulated a wave of research not only on the use of hCG-based
vaccines, but on other antigens as well.
General
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