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Creatine Kinase Isoenzymes - Pathophysiology and Clinical Application (Paperback)
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Creatine Kinase Isoenzymes - Pathophysiology and Clinical Application (Paperback)
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No one has counted the enzymes in the human organism, and probably
their profuse number can only be estimated from the restrictions
the finite mass of genetic material imposes. Still, nu merous
catalytic activities have been identified and investigated for
their clinical relevance. After one century of such research,
surprisingly, only a handful of enzymes has survived the stern
trial of clinical application to find regular medical use. Dis
regarding genetic defects, most of the diagnostically used en zymes
participate in metabolic conversions fundamental to life: the
utilization, transfer or fixation of vital nutrients or of
cheJ,llical energy. Creatine kinase is central to the function of
the mitochond rion, the cellular power generator. The wider
distribution of this enzyme is linked to tissues whose physiology
crucially relies on an adaptable supply of energy, notably skeletal
muscle, the brain, and the heart. Just as these three tissues vary
in their pre ference for different energy sources, each produces a
different isoenzyme of creatine kinase. Accordingly, the finding of
elevat ed creatine kinase activity in blood can lead to a variety
of interpretations, but in practice the diagnosis of acute
myocardial infarction is the major consideration.
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