In this study, controlled release matrix tablets containing
cephelexin were prepared using HPMC15 cps and Eudragit L100 in
different concentration by Direct compression method. Tablets were
evaluated for physical properties, Hardness, friability, weight
variation and In vitro dissolution study was carried on USP II
apparetus (peddle type). The best formulations selected based on
above parameters were subjected for Extend release study with use
of different ratio of polymer as Eudragit and HPMC .The tablets
with Eudragit were found to release drug for longer duration of
time as compared to formulations containing HPMC. The drug release
from the tablets was sufficiently sustained.
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