The development of drug-resistant cancers is considered to be the
most significant obstacle to the cure of cancer today. Nearly half
of all patients with cancer suffer from tumours that are
intrinsically resistant to chemotherapy, and most of the remaining
half develop drug resistance during the course of their treatment.
This book reviews the mechanisms and clinical implications of drug
resistance in cancer with unrivalled authority. Chapters cover
topics of current clinical concern, including multiple drug
resistance and its reversal, topoisomerase drugs, apoptosis, dose
intensity and escalation, gene therapy and haematopoietic support.
The authors are among the leading clinicians and investigators in
the field. These authoritative volumes in this series are intended
for a wide audience of clinicians and researchers with an interest
in the applications of biomedical science to the understanding and
management of cancer.
General
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