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Books > Medicine > Other branches of medicine > Pharmacology
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Antifolate Drugs in Cancer Therapy (Hardcover, 1999 ed.)
Loot Price: R5,996
Discovery Miles 59 960
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Antifolate Drugs in Cancer Therapy (Hardcover, 1999 ed.)
Series: Cancer Drug Discovery and Development
Expected to ship within 10 - 15 working days
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Antifolates are an important class of anticancer drugs originally
developed as anti leu- kemic agents, but now used, usually in
combination with other drugs, for the treatment of a wide range of
tumors, notably carcinomas of the head and neck, breast, germ cell
tumors, non-Hodgkin's lymphoma, acute lymphoblastic leukemia, and
osteogenic sar- comas. 5-Fluorouracil and its prodrugs also target,
in part, the folate-dependent enzyme, thymidylate synthase.
Furthermore, folate supplementation in the form of leucovorin,
modulates 5-fluororuacil activity. 5-Fluorouracil is widely used in
the treatment of colorectal and gastric cancer and in combination
for other solid tumors such as breast and head and neck cancers.
Ongoing clinical trials with the newer antifolates suggest that the
range of solid tumors where these agents will be of use may broaden
further. Half a century ago, interesting scientific and clinical
discoveries suggested that folie acid was a vitamin involved in
vital cellular metabolic processes. The folate analogs, aminopterin
and methotrexate, were synthesized by the American Cyanamid Company
in an attempt to interfere with these processes and were shown to
have anticancer activity by Farber and his colleagues. Hence, the
principle of antimetabolite therapy for the treatment of cancer was
established. Biomedical research over the following years led to a
deeper understanding of the complex biochemical pharmacology of
folates and antifolates. Selective antimicrobial agents were
discovered, but more tumor-selective anticancer agents did not
immediately emerge.
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