Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease (Hardcover, 2nd ed. 2003)

One of the most important developments in the field of cardiovascular medicine over the last two decades has been recognition of the key role played by arterial thrombosis in the pathogenesis of acute coronary syndromes, ischemic complications of percutane- ous coronary revascularization, and coronary and peripheral atherosclerosis. The phar- macologic armamentarium directed against vascular thrombosis has thus expanded substantially during that time, with development of new fibrinolytic agents, low-molecu- lar-weight heparins, direct thrombin inhibitors, antagonists to platelet activation, and the platelet glycoprotein lIb/IlIa inhibitors. Though clinical investigations of these com- pounds have been marked by failures as well as successes, there is little doubt that enhanced antithrombotic therapies have markedly improved the outcome of patients undergoing coronary revascularization or with acute coronary syndromes. Glycoprotein IIblIlIa receptor antagonists were introduced into clinical practice to overcome the limitations of approaches that inhibit only individual pathways of platelet activation. Multiple mechanisms of platelet activation in response to different agonists converge on the platelet membrane glycoprotein IIblIlIa complex, the "final common pathway" of platelet aggregation. The clinical hemorrhagic syndrome caused by a rare inherited defect in this receptor (Glanzmann' s thrombasthenia), characterized by muco- cutaneous and postsurgical bleeding, but infrequent spontaneous organ (particularly central nervous system) bleeding, suggested that therapeutic inhibition of this receptor might be a potent, yet well-tolerated means of treating thrombotic disorders.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Contemporary Cardiology
Release date:	March 2003
First published:	2003
Editors:	A.Michael Lincoff
Dimensions:	254 x 178 x 26mm (L x W x T)
Format:	Hardcover
Pages:	476
Edition:	2nd ed. 2003
ISBN-13:	978-1-58829-185-1
Categories:	Books > Medicine > Clinical & internal medicine > Cardiovascular medicine Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > Chemotherapy Promotions
LSN:	1-58829-185-5
Barcode:	9781588291851

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