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Hydrogel based nanoparticulate ocular drug delivery systems (Paperback)
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Hydrogel based nanoparticulate ocular drug delivery systems (Paperback)
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Poor ocular bioavailability of drugs (> 1%) from conventional
eye drops (i.e. solution, suspension and ointments) is mainly due
to the precorneal loss factor. Ocular efficacy is closely related
to ocular drug bioavailability, which may be enhanced by increasing
corneal drug penetration and prolonging precorneal drug residence
time. Sparfloxacin and levofloxacin are newer generation
hydrophobic fluoroquinolones. Poorly water soluble drugs are
difficult to develop as conventional ocular drug delivery system.
Nanotechnology can be used to formulate poorly water soluble drugs
as nanosuspension which can be further incorporated in to matrix of
hydrogel. This combination thus offers the opportunity to address
many of the formulation related issues with such drugs. A variety
of ocular drug delivery systems, such as hydrogels, microparticles,
nanoparticles, microemulsion, liposomes and collagen shields have
been designed and investigated for improved ocular bioavailability.
Amongst them, hydrogels and polymeric nanoparticles are the most
interesting approaches to achieve local sustained delivery system.
In the present work various hydrogel based systems are developed
and evaluated.
General
Imprint: |
Lap Lambert Academic Publishing
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Country of origin: |
Germany |
Release date: |
March 2012 |
First published: |
March 2012 |
Authors: |
Himanshu Gupta
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Dimensions: |
229 x 152 x 17mm (L x W x T) |
Format: |
Paperback - Trade
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Pages: |
292 |
ISBN-13: |
978-3-8484-2234-0 |
Categories: |
Books >
Medicine >
Other branches of medicine >
Pharmacology >
General
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LSN: |
3-8484-2234-4 |
Barcode: |
9783848422340 |
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