In the past decade we have witnessed the birth and maturing of a
field of research centering on the Ca2+ signaling functions of
cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide
phosphate (NAADP), which structures and mechanisms of action are
truly unique among all Ca2+ messengers. A wide range of
physiological functions are now known to be mediated by them in
cells spanning three biological kingdoms from protist, plant to
animal. This is the first book devoted entirely to the field. The
story behind the emergence of the field is told and followed by
comprehensive reviews of the enzymology, regulations and gene
structures of ADP-ribosyl cyclases responsible for metabolizing
cADPR and NAADP. Also covered is some of the current methodology
developed for and widely used in the field. The rest of the book
focuses on and details the Ca2+ signaling mechanisms and specific
physiological functions of these two messengers in various cellular
systems.
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