Osteoblasts are highly specialised mesenchymal cells that are
mainly responsible for the formation and maintenance of the
skeletal architecture. They produce extracellular matrix proteins
and are regulators of matrix mineralisation during bone formation
and remodelling. In this book, the authors discuss the morphology,
functions and clinical implications of osteoblasts. Topics include
osteoblasts under mechanical strain; mesenchymal stem cells (MSC)
into osteoblasts for bone tissue engineering; osteoblast function
and their role in skeletal bone diseases; bone morphogenetic
proteins (BMP) and osteoblastogenesis inhibitors; the effect of
molecular and biochemical differentiation agents on bone formation;
and the evaluation of characteristics of osteoblasts and factors
related to osteoblastic differentiation and mineralisation.
General
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