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Books > Medicine > Clinical & internal medicine > Haematology
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In VIVO Footprinting, Volume 21 (Hardcover)
Loot Price: R2,900
Discovery Miles 29 000
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In VIVO Footprinting, Volume 21 (Hardcover)
Series: Advances in Molecular & Cell Biology
Expected to ship within 12 - 19 working days
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The revolution in biological research initiated by the
demonstration that particular DNA molecules could be isolated,
recombined in novel ways, and conveniently replicated to high copy
number in vivo for further study, that is, the recombinant DNA era,
has spawned many additional advances, both methodological and
intellectual, that have enhanced our understanding of cellular
processes to an astonishing degree. As part of the subsequent
outpouring of information, research exploring the mechanisms of
gene regulation, both in prokaryotes and eukaryotes (but
particularly the latter), has been particularly well represented.
Although no one technical approach can be said to have brought the
filed to its current level of sophistication, the ability to map
the interactions of trans-acting factors with their DNA recognition
sequences to a high level of precision has certainly been one of
the more important advances. This "footprinting" approach has
become almost ubiquitous in gene regulatory studies; however, it is
in its ""in vivo"" application that ambiguities, confusions, and
inconsistencies that may arise from a purely ""in vitro""-based
approach can often be resolved and placed in their proper
perspective. Put more simply, that an interaction can be
demonstrated to occur between purified factors and a particular
piece of DNA in a test tube does not, of course, say anything
regarding whether such interactions are occurring "in vivo." The
ability to probe for such interactions as they occur inside cells,
with due attention paid to the relevant developmental stage, or to
the tissue specificity of the interaction being probed, has made
"in vivo" footprinting approach an invaluable adjunct to the "gene
jockey's" arsenal of weapons.
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