Diverse alterations of glycosylation occur in diseases such as
cancer, metastasis, leukemia, inflammatory and other diseases. The
glycosylation abnormalities found in disease are the result of
complex rearrangements of the oligosaccharide assembly by
glycosyltransferases. This volume reviews several mechanisms that
may underly the extremely complex alterations in disease. Disease
specific glycosylation may contribute to the disease process by
altering cellular functions, or may be exploited therapeutically.
Specific therapy may be aimed at correcting glycosylation
abnormalities based on knowledge of the mechanisms leading to the
disease phenotype and the three-dimensional interactions between
carbohydrates and carbohydrate-binding molecules.
General
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