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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Basic and Clinical Neurocardiology (Hardcover, New)
Loot Price: R3,369
Discovery Miles 33 690
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Basic and Clinical Neurocardiology (Hardcover, New)
Expected to ship within 12 - 19 working days
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The progression of heart disease is associated with changes in the
neurohumoral mechanisms that control cardiac function. The degree
to which this neurohumoral remodelling occurs, even before overt
signs of cardiac disease become manifest, is important for
prognosis. To determine why some patients experience sudden death
while others sustain life in the presence of severely compromised
cardiac function, the neuronal control of cardiac electrical and
mechanical events must be considered. Starting at the level of
individual neurons and building upwards, this book describes the
synergistic interactions that occur among intrathoracic and CNS
feedback loops to permit precise control of regional cardiac
behaviour. On this basic science foundation, subsequent clinical
chapters explore the remodelling that occurs in this system with
ageing, with the evolution of specific cardiac pathologies, and
with the psychological concomitants of heart disease. Most
importantly, these chapters provide unique insights into how
specific therapies like beta-andrenergic receptor blockade not only
affect cardiomyocytes directly but also mitigate the adverse
neurohumoral changes that accompany disease processes, such as
heart failure and essential hypertension. The paradigm advanced in
this volume is that heart disease is a multifaceted phenomenon
involving the interplay of neurohumoral, cardiomyocyte and
structural elements, each of which depends on the other. With our
cumulative understanding of these interdependent processes, new
avenues for time-appropriate, targeted methods of treating heart
diseases can be developed.
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